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Hydrophobic Determinants of α-Defensin Bactericidal Activity

Mammalian α-defensins are approximately 4- to 5-kDa broad-spectrum antimicrobial peptides and abundant granule constituents of neutrophils and small intestinal Paneth cells. The bactericidal activities of amphipathic α-defensins depend in part on electropositive charge and on hydrophobic amino acids...

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Detalhes bibliográficos
Main Authors: Tai, Kenneth P., Le, Valerie V., Selsted, Michael E., Ouellette, André J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019156/
https://ncbi.nlm.nih.gov/pubmed/24614658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01414-13
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