Alternative Luminal Activation Mechanisms for Paneth Cell α-Defensins

Paneth cell α-defensins mediate host defense and homeostasis at the intestinal mucosal surface. In mice, matrix metalloproteinase-7 (MMP7) converts inactive pro-α-defensins (proCrps) to bactericidal forms by proteolysis at specific proregion cleavage sites. MMP7(−/−) mice lack mature α-defensins in...

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Autori principali: Mastroianni, Jennifer R., Costales, Jessica K., Zaksheske, Jennifer, Selsted, Michael E., Salzman, Nita H., Ouellette, André J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Protein Synthesis and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322892/
https://ncbi.nlm.nih.gov/pubmed/22334698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333559
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