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Alternative Luminal Activation Mechanisms for Paneth Cell α-Defensins
Paneth cell α-defensins mediate host defense and homeostasis at the intestinal mucosal surface. In mice, matrix metalloproteinase-7 (MMP7) converts inactive pro-α-defensins (proCrps) to bactericidal forms by proteolysis at specific proregion cleavage sites. MMP7(−/−) mice lack mature α-defensins in...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3322892/ https://ncbi.nlm.nih.gov/pubmed/22334698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333559 |
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