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Inhibition of bactericidal activity is maintained in a mouse α-defensin precursor with proregion truncations
α-Defensin biosynthesis requires the proteolytic conversion of inactive precursors to microbicidal forms. In mouse Paneth cell pro-α-defensin proCrp4((20–92)), anionic amino acids positioned near the proregion N-terminus inhibit proCrp4 activity by an apparent charge neutralization mechanism. Becaus...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2814988/ https://ncbi.nlm.nih.gov/pubmed/19837119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2009.10.004 |
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