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USP28 Is Recruited to Sites of DNA Damage by the Tandem BRCT Domains of 53BP1 but Plays a Minor Role in Double-Strand Break Metabolism

The DNA damage response (DDR) is critical for genome stability and the suppression of a wide variety of human malignancies, including neurodevelopmental disorders, immunodeficiency, and cancer. In addition, the efficacy of many chemotherapeutic strategies is dictated by the status of the DDR. Ubiqui...

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Библиографические подробности
Главные авторы: Knobel, Philip A., Belotserkovskaya, Rimma, Galanty, Yaron, Schmidt, Christine K., Jackson, Stephen P., Stracker, Travis H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019063/
https://ncbi.nlm.nih.gov/pubmed/24687851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00197-14
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