N(pro) of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites

Classical swine fever (CSF) caused by CSF virus (CSFV) is a highly contagious disease of pigs. The viral protein N(pro) of CSFV interferes with alpha- and beta-interferon (IFN-α/β) induction by promoting the degradation of interferon regulatory factor 3 (IRF3). During the establishment of the live a...

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Autors principals: Tamura, Tomokazu, Nagashima, Naofumi, Ruggli, Nicolas, Summerfield, Artur, Kida, Hiroshi, Sakoda, Yoshihiro
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018971/
https://ncbi.nlm.nih.gov/pubmed/24742209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1297-9716-45-47
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