Classical Swine Fever Virus Can Remain Virulent after Specific Elimination of the Interferon Regulatory Factor 3-Degrading Function of N(pro)

Pestiviruses prevent alpha/beta interferon (IFN-α/β) production by promoting proteasomal degradation of interferon regulatory factor 3 (IRF3) by means of the viral N(pro) nonstructural protein. N(pro) is also an autoprotease, and its amino-terminal coding sequence is involved in translation initiati...

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Detalhes bibliográficos
Main Authors: Ruggli, Nicolas, Summerfield, Artur, Fiebach, Ana R., Guzylack-Piriou, Laurence, Bauhofer, Oliver, Lamm, Catherine G., Waltersperger, Sandro, Matsuno, Keita, Liu, Luzia, Gerber, Markus, Choi, Kyung H., Hofmann, Martin A., Sakoda, Yoshihiro, Tratschin, Jon-Duri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612357/
https://ncbi.nlm.nih.gov/pubmed/18987150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01509-08
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