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Deregulation of FoxO3a Accelerates Prostate Cancer Progression in TRAMP Mice

BACKGROUND: Forkhead box, class “O” (FoxO) transcription factors are involved in multiple signaling pathways and possess tumor suppressor functions. Loss of PTEN and activation of PI3K/Akt is frequently observed in prostate cancer, which may potentially inactivate FoxO activity. We therefore investi...

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Hlavní autoři: Shukla, Sanjeev, Bhaskaran, Natarajan, MacLennan, Gregory T, Gupta, Sanjay
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018753/
https://ncbi.nlm.nih.gov/pubmed/23765843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22698
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