Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice

Aberrant Nuclear Factor-κappaB (NF-κB) activation due to rapid IκBα turnover and high basal IκBα kinase (IKK) activity has been frequently observed in prostate cancer. Apigenin, a naturally occurring plant flavone, exhibits anti-proliferative, anti-inflammatory and anti-carcinogenic activities by in...

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Bibliographic Details
Published in:PLoS One
Main Authors: Shukla, Sanjeev, Shankar, Eswar, Fu, Pingfu, MacLennan, Gregory T., Gupta, Sanjay
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574560/
https://ncbi.nlm.nih.gov/pubmed/26379052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138710
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