Modelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensitive

Fertilization of sea urchin eggs involves an increase in protein synthesis associated with a decrease in the amount of the translation initiation inhibitor 4E-BP. A highly simple reaction model for the regulation of protein synthesis was built and was used to simulate the physiological changes in th...

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Detalhes bibliográficos
Main Authors: Laurent, Sébastien, Richard, Adrien, Mulner-Lorillon, Odile, Morales, Julia, Flament, Didier, Glippa, Virginie, Bourdon, Jérémie, Gosselin, Pauline, Siegel, Anne, Cormier, Patrick, Bellé, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018528/
https://ncbi.nlm.nih.gov/pubmed/24834072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00117
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