Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos

The cyclin B/CDK1 complex is a key regulator of mitotic entry. Using PP242, a specific ATP-competitive inhibitor of mTOR kinase, we provide evidence that the mTOR signalling pathway controls cyclin B mRNA translation following fertilization in Sphaerechinus granularis and Paracentrotus lividus. We s...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Chassé, Héloïse, Mulner-Lorillon, Odile, Boulben, Sandrine, Glippa, Virginie, Morales, Julia, Cormier, Patrick
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786324/
https://ncbi.nlm.nih.gov/pubmed/26962866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150318
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