Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain

Tapentadol is a dual action molecule with mu opioid agonist and norepinephrine (NE) reuptake blocking activity that has recently been introduced for the treatment of moderate to severe pain. The effects of intraperitoneal (i.p.) morphine (10 mg/kg), tapentadol (10 or 30 mg/kg) or duloxetine (30 mg/k...

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Bibliographic Details
Main Authors: Meske, Diana S., Xie, Jennifer Y., Oyarzo, Janice, Badghisi, Hamid, Ossipov, Michael H., Porreca, Frank
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018237/
https://ncbi.nlm.nih.gov/pubmed/23969300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.08.017
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