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Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain

Tapentadol is a dual action molecule with mu opioid agonist and norepinephrine (NE) reuptake blocking activity that has recently been introduced for the treatment of moderate to severe pain. The effects of intraperitoneal (i.p.) morphine (10 mg/kg), tapentadol (10 or 30 mg/kg) or duloxetine (30 mg/k...

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Hlavní autoři: Meske, Diana S., Xie, Jennifer Y., Oyarzo, Janice, Badghisi, Hamid, Ossipov, Michael H., Porreca, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018237/
https://ncbi.nlm.nih.gov/pubmed/23969300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.08.017
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