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The effects of the β-agonist isoproterenol on the down-regulation, functional responsiveness, and trafficking of β(2)-adrenergic receptors with amino-terminal polymorphisms

The β(2)-adrenergic receptor (β(2)AR) is an important target for respiratory and cardiovascular disease medications. Clinical studies suggest that amino-terminal polymorphisms of the β(2)AR may act as disease modifiers. We hypothesized that polymorphisms at amino acids 16 and 27 result in differenti...

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Main Authors: Koryakina, Yulia, Jones, Stacie M., Cornett, Lawrence E., Seely, Kathryn, Brents, Lisa, Prather, Paul L., Kofman, Alexander, Kurten, Richard C.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018189/
https://ncbi.nlm.nih.gov/pubmed/22938397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CBI20120134
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