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MicroRNA let-7 establishes expression of β(2)-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation
Although β(2)-adrenergic receptors (β(2)AR) are expressed on most cell types, mechanisms that establish expression levels and regulate expression by chronic agonist remain unclear. The 3′ UTR of ADRB2 has a conserved 8-nucleotide seed region that we hypothesized is targeted by the let-7 family of mi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076830/ https://ncbi.nlm.nih.gov/pubmed/21447718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101439108 |
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