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Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity

The sequence and roles in developmental progression of the microRNA let-7 are conserved. In general, transcription of the let-7 primary transcript (pri-let-7) occurs early in development, whereas processing of the mature let-7 microRNA arises during cellular differentiation. In Caenorhabditis elegan...

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Bibliografische gegevens
Gepubliceerd in:Development
Hoofdauteurs: Nelson, Charles, Ambros, Victor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists Ltd 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432665/
https://ncbi.nlm.nih.gov/pubmed/30770392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.172031
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