Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue

[Image: see text] Deoxygenation of the diol groups in rings A and D of neomycin in combination with the introduction of an N1-(l)-HABA group in the 2-deoxystreptamine subunit (ring B) leads to a novel and potent antibiotic (1) with activity against strains of S. aureus carrying known aminoglycoside...

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Main Authors: Hanessian, Stephen, Giguère, Alexandre, Grzyb, Justyna, Maianti, Juan Pablo, Saavedra, Oscar M., Aggen, James B., Linsell, Martin S., Goldblum, Adam A., Hildebrandt, Darin J., Kane, Timothy R., Dozzo, Paola, Gliedt, Micah J., Matias, Rowena D., Feeney, Lee Ann, Armstrong, Eliana S.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2011
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018147/
https://ncbi.nlm.nih.gov/pubmed/24900282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200202y
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