Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue

[Image: see text] Deoxygenation of the diol groups in rings A and D of neomycin in combination with the introduction of an N1-(l)-HABA group in the 2-deoxystreptamine subunit (ring B) leads to a novel and potent antibiotic (1) with activity against strains of S. aureus carrying known aminoglycoside...

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Hlavní autoři: Hanessian, Stephen, Giguère, Alexandre, Grzyb, Justyna, Maianti, Juan Pablo, Saavedra, Oscar M., Aggen, James B., Linsell, Martin S., Goldblum, Adam A., Hildebrandt, Darin J., Kane, Timothy R., Dozzo, Paola, Gliedt, Micah J., Matias, Rowena D., Feeney, Lee Ann, Armstrong, Eliana S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2011
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018147/
https://ncbi.nlm.nih.gov/pubmed/24900282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200202y
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