Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue

[Image: see text] Deoxygenation of the diol groups in rings A and D of neomycin in combination with the introduction of an N1-(l)-HABA group in the 2-deoxystreptamine subunit (ring B) leads to a novel and potent antibiotic (1) with activity against strains of S. aureus carrying known aminoglycoside...

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Autori principali: Hanessian, Stephen, Giguère, Alexandre, Grzyb, Justyna, Maianti, Juan Pablo, Saavedra, Oscar M., Aggen, James B., Linsell, Martin S., Goldblum, Adam A., Hildebrandt, Darin J., Kane, Timothy R., Dozzo, Paola, Gliedt, Micah J., Matias, Rowena D., Feeney, Lee Ann, Armstrong, Eliana S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2011
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018147/
https://ncbi.nlm.nih.gov/pubmed/24900282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200202y
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