Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors

[Image: see text] Following from the evaluation of different types of electrophiles, combined modeling and crystallographic analyses are used to generate potent boronic acid based inhibitors of a penicillin binding protein. The results suggest that a structurally informed approach to penicillin bind...

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Detalhes bibliográficos
Main Authors: Woon, Esther C. Y., Zervosen, Astrid, Sauvage, Eric, Simmons, Katie J., Živec, Matej, Inglis, Steven R., Fishwick, Colin W. G., Gobec, Stanislav, Charlier, Paulette, Luxen, André, Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018096/
https://ncbi.nlm.nih.gov/pubmed/24900305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100260x
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