New Noncovalent Inhibitors of Penicillin-Binding Proteins from Penicillin-Resistant Bacteria

BACKGROUND: Penicillin-binding proteins (PBPs) are well known and validated targets for antibacterial therapy. The most important clinically used inhibitors of PBPs β-lactams inhibit transpeptidase activity of PBPs by forming a covalent penicilloyl-enzyme complex that blocks the normal transpeptidat...

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Autors principals: Turk, Samo, Verlaine, Olivier, Gerards, Thomas, Živec, Matej, Humljan, Jan, Sosič, Izidor, Amoroso, Ana, Zervosen, Astrid, Luxen, André, Joris, Bernard, Gobec, Stanislav
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090393/
https://ncbi.nlm.nih.gov/pubmed/21573060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019418
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