Genetic interactions affecting human gene expression identified by variance association mapping

Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci. Interactions give rise to genotype dependent variance, and therefore the identification of variance qu...

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Bibliografske podrobnosti
Main Authors: Brown, Andrew Anand, Buil, Alfonso, Viñuela, Ana, Lappalainen, Tuuli, Zheng, Hou-Feng, Richards, J Brent, Small, Kerrin S, Spector, Timothy D, Dermitzakis, Emmanouil T, Durbin, Richard
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2014
Teme:
Genes and Chromosomes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017648/
https://ncbi.nlm.nih.gov/pubmed/24771767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01381
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