Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia

TP53 mutations are strong predictors of poor survival and refractoriness in chronic lymphocytic leukemia (CLL) and have direct implications for disease management. Clinical information on TP53 mutations is limited to lesions represented in >20% leukemic cells. Here, we tested the clinical impact...

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Main Authors: Rossi, Davide, Khiabanian, Hossein, Spina, Valeria, Ciardullo, Carmela, Bruscaggin, Alessio, Famà, Rosella, Rasi, Silvia, Monti, Sara, Deambrogi, Clara, De Paoli, Lorenzo, Wang, Jiguang, Gattei, Valter, Guarini, Anna, Foà, Robin, Rabadan, Raul, Gaidano, Gianluca
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2014
Fag:
Plenary Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017291/
https://ncbi.nlm.nih.gov/pubmed/24501221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-11-539726
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