Molecular Basis and Regulation of OTULIN-LUBAC Interaction

The linear ubiquitin (Ub) chain assembly complex (LUBAC) generates Met1-linked “linear” Ub chains that regulate the activation of the nuclear factor κB (NFκB) transcription factor and other processes. We recently discovered OTULIN as a deubiquitinase that specifically cleaves Met1-linked polyUb. Now...

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Main Authors: Elliott, Paul R., Nielsen, Sofie V., Marco-Casanova, Paola, Fiil, Berthe Katrine, Keusekotten, Kirstin, Mailand, Niels, Freund, Stefan M.V., Gyrd-Hansen, Mads, Komander, David
格式: Artigo
語言:Inglês
出版: Cell Press 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017264/
https://ncbi.nlm.nih.gov/pubmed/24726323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.03.018
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