OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

The linear ubiquitin (Ub) chain assembly complex (LUBAC) is an E3 ligase that specifically assembles Met1-linked (also known as linear) Ub chains that regulate nuclear factor κB (NF-κB) signaling. Deubiquitinases (DUBs) are key regulators of Ub signaling, but a dedicated DUB for Met1 linkages has no...

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Main Authors: Keusekotten, Kirstin, Elliott, Paul Ronald, Glockner, Laura, Fiil, Berthe Katrine, Damgaard, Rune Busk, Kulathu, Yogesh, Wauer, Tobias, Hospenthal, Manuela Kathrin, Gyrd-Hansen, Mads, Krappmann, Daniel, Hofmann, Kay, Komander, David
Format: Artigo
Language:Inglês
Published: Cell Press 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690481/
https://ncbi.nlm.nih.gov/pubmed/23746843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.05.014
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