Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

SLX4 binds to three nucleases (XPF-ERCC1, MUS81-EME1, and SLX1), and its deficiency leads to genomic instability, sensitivity to DNA crosslinking agents, and Fanconi anemia. However, it is not understood how SLX4 and its associated nucleases act in DNA crosslink repair. Here, we uncover consequences...

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Hauptverfasser: Hodskinson, Michael R.G., Silhan, Jan, Crossan, Gerry P., Garaycoechea, Juan I., Mukherjee, Shivam, Johnson, Christopher M., Schärer, Orlando D., Patel, Ketan J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017094/
https://ncbi.nlm.nih.gov/pubmed/24726326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.03.014
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