Mislocalization of XPF-ERCC1 Nuclease Contributes to Reduced DNA Repair in XP-F Patients

Xeroderma pigmentosum (XP) is caused by defects in the nucleotide excision repair (NER) pathway. NER removes helix-distorting DNA lesions, such as UV–induced photodimers, from the genome. Patients suffering from XP exhibit exquisite sun sensitivity, high incidence of skin cancer, and in some cases n...

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Hlavní autoři: Ahmad, Anwaar, Enzlin, Jacqueline H., Bhagwat, Nikhil R., Wijgers, Nils, Raams, Anja, Appledoorn, Esther, Theil, Arjan F., J. Hoeijmakers, Jan H., Vermeulen, Wim, J. Jaspers, Nicolaas G., Schärer, Orlando D., Niedernhofer, Laura J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832669/
https://ncbi.nlm.nih.gov/pubmed/20221251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000871
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