Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer

BACKGROUND: Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary thyroid carcinoma (PTC). Genetic mechanisms underlying NRF2 pathway activation in PTC are not fully u...

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Detalhes bibliográficos
Main Authors: Martinez, Victor D, Vucic, Emily A, Pikor, Larissa A, Thu, Kelsie L, Hubaux, Roland, Lam, Wan L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016213/
https://ncbi.nlm.nih.gov/pubmed/24138990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-124
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