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The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation

BACKGROUND: Microtubule stabilizers suppress microtubule dynamics and, at the lowest antiproliferative concentrations, disrupt the function of mitotic spindles, leading to mitotic arrest and apoptosis. At slightly higher concentrations, these agents cause the formation of multiple mitotic asters wit...

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Detalhes bibliográficos
Main Authors: Risinger, April L, Riffle, Stephen M, Lopus, Manu, Jordan, Mary A, Wilson, Leslie, Mooberry, Susan L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015978/
https://ncbi.nlm.nih.gov/pubmed/24576146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-41
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