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PHLPP regulates the development, function and molecular signaling pathways of T regulatory cells()
Tregs have a reduced capacity to activate the PI3K/Akt pathway downstream of the TCR, and the resulting low activity of Akt is necessary for their development and function. The molecular basis for the failure of Tregs to efficiently activate Akt, however, remained unknown. We show that PH-domain Leu...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4015973/ https://ncbi.nlm.nih.gov/pubmed/21498666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002126 |
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