Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock

The pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) differentially attenuates Akt, PKC, and ERK1/2 signaling, thereby controlling the duration and amplitude of responses evoked by these kinases. PHLPP1 is expressed in the mammalian central clock, the suprachiasmatic nuc...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Masubuchi, Satoru, Gao, Tianyan, O'Neill, Audrey, Eckel-Mahan, Kristin, Newton, Alexandra C., Sassone-Corsi, Paolo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2010
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824391/
https://ncbi.nlm.nih.gov/pubmed/20080691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910292107
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