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Identification of parameter correlations for parameter estimation in dynamic biological models

BACKGROUND: One of the challenging tasks in systems biology is parameter estimation in nonlinear dynamic models. A biological model usually contains a large number of correlated parameters leading to non-identifiability problems. Although many approaches have been developed to address both structura...

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Autors principals: Li, Pu, Vu, Quoc Dong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015753/
https://ncbi.nlm.nih.gov/pubmed/24053643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-7-91
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