Novel Vitamin D Analogs as Potential Therapeutics: The Metabolism, Toxicity Profiling, and Antiproliferative Activity

AIM: To discover novel [20(OH)D(3)] analogs as antiproliferative therapeutics. MATERIALS AND METHODS: We studied in vitro liver microsome stability, in vivo toxicity using mice, vitamin D receptor (VDR) translocation, in vitro antiproliferative effect, CYP enzyme metabolism. RESULTS: 20S- and 20R(OH...

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Autors principals: CHEN, JIANJUN, WANG, JIN, KIM, TAE-KANG, TIEU, ELAINE W, TANG, EDITH K.Y., LIN, ZONGTAO, KOVACIC, DIANNE, MILLER, DUANE D., POSTLETHWAITE, ARNOLD, TUCKEY, ROBERT C., SLOMINSKI, ANDRZEJ T., LI, WEI
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015637/
https://ncbi.nlm.nih.gov/pubmed/24778017
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