CONVERGENCE OF P53 AND TGFβ SIGNALING ON ACTIVATING EXPRESSION OF THE TUMOR SUPPRESSOR GENE MASPIN IN MAMMARY EPITHELIAL CELLS

Using two-dimensional difference gel electrophoresis, we identified the tumor suppressor gene maspin as a TGFβ target gene in human mammary epithelial cells. TGFβ upregulates maspin expression both at the RNA and protein levels. This upregulation required Smad2/3 function and intact p53 binding elem...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Shizhen Emily, Narasanna, Archana, Whitell, Corbin W., Wu, Frederick Y., Friedman, David B., Arteaga, Carlos L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015524/
https://ncbi.nlm.nih.gov/pubmed/17204482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M608499200
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