CONVERGENCE OF P53 AND TGFβ SIGNALING ON ACTIVATING EXPRESSION OF THE TUMOR SUPPRESSOR GENE MASPIN IN MAMMARY EPITHELIAL CELLS

Using two-dimensional difference gel electrophoresis, we identified the tumor suppressor gene maspin as a TGFβ target gene in human mammary epithelial cells. TGFβ upregulates maspin expression both at the RNA and protein levels. This upregulation required Smad2/3 function and intact p53 binding elem...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Wang, Shizhen Emily, Narasanna, Archana, Whitell, Corbin W., Wu, Frederick Y., Friedman, David B., Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015524/
https://ncbi.nlm.nih.gov/pubmed/17204482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M608499200
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares