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Lysosomal NEU1 deficiency affects Amyloid Precursor Protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

Alzheimer’s disease (AD) belongs to a category of adult neurodegenerative conditions which are associated with intracellular and extracellular accumulation of neurotoxic protein aggregates. Understanding how these aggregates are formed, secreted and propagated by neurons has been the subject of inte...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Annunziata, Ida, Patterson, Annette, Helton, Danielle, Hu, Huimin, Moshiach, Simon, Gomero, Elida, Nixon, Ralph, d’Azzo, Alessandra
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015463/
https://ncbi.nlm.nih.gov/pubmed/24225533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3734
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