Fusion of HCV Nonstructural Antigen to MHC Class II–associated Invariant Chain Enhances T-cell Responses Induced by Vectored Vaccines in Nonhuman Primates

Despite viral vectors being potent inducers of antigen-specific T cells, strategies to further improve their immunogenicity are actively pursued. Of the numerous approaches investigated, fusion of the encoded antigen to major histocompatibility complex class II–associated invariant chain (Ii) has be...

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Bibliographische Detailangaben
Hauptverfasser: Capone, Stefania, Naddeo, Mariarosaria, D'Alise, Anna Morena, Abbate, Adele, Grazioli, Fabiana, Del Gaudio, Annunziata, Del Sorbo, Mariarosaria, Esposito, Maria Luisa, Ammendola, Virginia, Perretta, Gemma, Taglioni, Alessandra, Colloca, Stefano, Nicosia, Alfredo, Cortese, Riccardo, Folgori, Antonella
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015230/
https://ncbi.nlm.nih.gov/pubmed/24476798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.15
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