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Limitations of Encapsidation of Recombinant Self-Complementary Adeno-Associated Viral Genomes in Different Serotype Capsids and Their Quantitation

We previously reported that self-complementary adeno-associated virus (scAAV) type 2 genomes of up to 3.3 kb can be successfully encapsidated into AAV2 serotype capsids. Here we report that such oversized AAV2 genomes fail to undergo packaging in other AAV serotype capsids, such as AAV1, AAV3, AAV6,...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Wang, Yuan, Ling, Chen, Song, Liujiang, Wang, Lina, Aslanidi, George V., Tan, Mengqun, Ling, Changquan, Srivastava, Arun
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Mary Ann Liebert, Inc. 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015078/
https://ncbi.nlm.nih.gov/pubmed/22966785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2012.090
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