Quantification of Dynamic Morphological Drug Responses in 3D Organotypic Cell Cultures by Automated Image Analysis

Glandular epithelial cells differentiate into complex multicellular or acinar structures, when embedded in three-dimensional (3D) extracellular matrix. The spectrum of different multicellular morphologies formed in 3D is a sensitive indicator for the differentiation potential of normal, non-transfor...

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Bibliographische Detailangaben
Hauptverfasser: Härmä, Ville, Schukov, Hannu-Pekka, Happonen, Antti, Ahonen, Ilmari, Virtanen, Johannes, Siitari, Harri, Åkerfelt, Malin, Lötjönen, Jyrki, Nees, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014501/
https://ncbi.nlm.nih.gov/pubmed/24810913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096426
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