Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression

To achieve the extreme nuclear condensation necessary for sperm function, most histones are replaced with protamines during spermiogenesis in mammals. Mature sperm retain only a small fraction of nucleosomes, which are, in part, enriched on gene regulatory sequences, and recent findings suggest that...

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Autori principali: Ihara, Motomasa, Meyer-Ficca, Mirella L., Leu, N. Adrian, Rao, Shilpa, Li, Fan, Gregory, Brian D., Zalenskaya, Irina A., Schultz, Richard M., Meyer, Ralph G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014456/
https://ncbi.nlm.nih.gov/pubmed/24810616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004317
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