Poly(ADP-Ribose) Polymerases PARP1 and PARP2 Modulate Topoisomerase II Beta (TOP2B) Function During Chromatin Condensation in Mouse Spermiogenesis

To achieve the specialized nuclear structure in sperm necessary for fertilization, dramatic chromatin reorganization steps in developing spermatids are required where histones are largely replaced first by transition proteins and then by protamines. This entails the transient formation of DNA strand...

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Detalhes bibliográficos
Main Authors: Meyer-Ficca, Mirella L., Lonchar, Julia D., Ihara, Motomasa, Meistrich, Marvin L., Austin, Caroline A., Meyer, Ralph G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for the Study of Reproduction, Inc. 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080419/
https://ncbi.nlm.nih.gov/pubmed/21228215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.110.090035
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