A Simulated Intermediate State for Folding and Aggregation Provides Insights into ΔN6 β(2)-Microglobulin Amyloidogenic Behavior

A major component of ex vivo amyloid plaques of patients with dialysis-related amyloidosis (DRA) is a cleaved variant of β(2)-microglobulin (ΔN6) lacking the first six N-terminal residues. Here we perform a computational study on ΔN6, which provides clues to understand the amyloidogenicity of the fu...

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Bibliografiske detaljer
Main Authors: Estácio, Sílvia G., Krobath, Heinrich, Vila-Viçosa, Diogo, Machuqueiro, Miguel, Shakhnovich, Eugene I., Faísca, Patrícia F. N.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014404/
https://ncbi.nlm.nih.gov/pubmed/24809460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003606
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