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A Simulated Intermediate State for Folding and Aggregation Provides Insights into ΔN6 β(2)-Microglobulin Amyloidogenic Behavior
A major component of ex vivo amyloid plaques of patients with dialysis-related amyloidosis (DRA) is a cleaved variant of β(2)-microglobulin (ΔN6) lacking the first six N-terminal residues. Here we perform a computational study on ΔN6, which provides clues to understand the amyloidogenicity of the fu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4014404/ https://ncbi.nlm.nih.gov/pubmed/24809460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003606 |
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