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Assessing the Effect of Loop Mutations in the Folding Space of β(2)-Microglobulin with Molecular Dynamics Simulations
We use molecular dynamics simulations of a full atomistic Gō model to explore the impact of selected DE-loop mutations (D59P and W60C) on the folding space of protein human β(2)-microglobulin (Hβ(2)m), the causing agent of dialysis-related amyloidosis, a conformational disorder characterized by the...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
MDPI
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3794727/ https://ncbi.nlm.nih.gov/pubmed/23975166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms140917256 |
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