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Assessing the Effect of Loop Mutations in the Folding Space of β(2)-Microglobulin with Molecular Dynamics Simulations

We use molecular dynamics simulations of a full atomistic Gō model to explore the impact of selected DE-loop mutations (D59P and W60C) on the folding space of protein human β(2)-microglobulin (Hβ(2)m), the causing agent of dialysis-related amyloidosis, a conformational disorder characterized by the...

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Bibliografske podrobnosti
Main Authors: Estácio, Sílvia G., Shakhnovich, Eugene I., Faísca, Patrícia F. N.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794727/
https://ncbi.nlm.nih.gov/pubmed/23975166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms140917256
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