Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice

Disorders of sex development in the human population range in severity from mild genital defects to gonadal sex reversal. XY female development has been associated with heterozygous mutations in several genes, including SOX9, WT1 and MAP3K1. In contrast, XY sex reversal in mice usually requires comp...

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Autori principali: Warr, Nick, Siggers, Pam, Carré, Gwenn-Aël, Bogani, Debora, Brixey, Rachel, Akiyoshi, Mika, Tachibana, Makoto, Teboul, Lydia, Wells, Sara, Sanderson, Jeremy, Greenfield, Andy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014197/
https://ncbi.nlm.nih.gov/pubmed/24452333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu020
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