A Novel Mouse Fgfr2 Mutant, Hobbyhorse (hob), Exhibits Complete XY Gonadal Sex Reversal

The secreted molecule fibroblast growth factor 9 (FGF9) plays a critical role in testis determination in the mouse. In embryonic gonadal somatic cells it is required for maintenance of SOX9 expression, a key determinant of Sertoli cell fate. Conditional gene targeting studies have identified FGFR2 a...

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Detalhes bibliográficos
Main Authors: Siggers, Pam, Carré, Gwenn-Aël, Bogani, Debora, Warr, Nick, Wells, Sara, Hilton, Helen, Esapa, Chris, Hajihosseini, Mohammad K., Greenfield, Andy
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067367/
https://ncbi.nlm.nih.gov/pubmed/24956260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100447
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