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Mapping of Allosteric Druggable Sites in Activation-Associated Conformers of the M2 Muscarinic Receptor
G-protein coupled receptors (GPCRs) are key cellular signaling proteins and have been targeted by ∼30-40% of marketed drugs for treating many human diseases including cancer and heart failure. Recently, we directly observed activation of the M2 muscarinic receptor through long-timescale accelerated...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4012891/ https://ncbi.nlm.nih.gov/pubmed/24112716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12233 |
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