Mapping the Druggable Allosteric Space of G-Protein Coupled Receptors: a Fragment-Based Molecular Dynamics Approach

To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based drug design of allosteric GPCR ligands has be...

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Bibliographic Details
Main Authors: Ivetac, Anthony, Andrew McCammon, J
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2010
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918726/
https://ncbi.nlm.nih.gov/pubmed/20626410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.01012.x
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