ELUCIDATING THE INHIBITION MECHANISM OF HIV-1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS THROUGH MULTI-COPY MOLECULAR DYNAMICS SIMULATIONS

HIV-1 reverse transcriptase (RT) inhibition is a major focus of current anti-AIDS drug discovery and development programs, comprising 17 of the 31 FDA-approved compounds. The emergence of the non-nucleoside RT inhibitor (NNRTI) class of compounds provides a highly specific and structurally diverse s...

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Hlavní autoři: Ivetac, Anthony, McCammon, J. Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744402/
https://ncbi.nlm.nih.gov/pubmed/19324058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.037
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