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Unbinding Dynamics of Non-Nucleoside Inhibitors from HIV-1 Reverse Transcriptase
Non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs), which bind to an allosteric site 10 −15Å from the polymerase active site, play a central role in anti-HIV chemotherapy. Though NNRTIs have been known for 30 years, the pathways by which they bind and unbind from HIV-RT have not been...
Gardado en:
| Publicado en: | J Phys Chem B |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6395492/ https://ncbi.nlm.nih.gov/pubmed/30571126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.8b10341 |
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